| 13 Stripes Brewery | 250 Mill St, Suite PW3101 | Taylors | South Carolina | 29687 | United States | brewpub | |
| Aiken Brewing Co | 140 Laurens St SW | Aiken | South Carolina | 29801-3848 | United States | brewpub | |
| Angry Fish Brewing Company | 106 Fabrister Ln Ste C | Lexington | South Carolina | 29072 | United States | micro | |
| Benford Brewing Co. | 2271 Boxcar Rd | Lancaster | South Carolina | 29720-9443 | United States | micro | |
| Birds Fly South Ale Project | 1320 Hampton Avenue Ext | Greenville | South Carolina | 29601-1012 | United States | micro | |
| Blue Ridge Brewing Co/Foothills Brewing | 308 Trade St | Greer | South Carolina | 29651-3432 | United States | brewpub | |
| Bomb Plant Brewing Company | | North Augusta | South Carolina | 29860-7462 | United States | planning | |
| Brewery 85 | 6 Whitlee Ct | Greenville | South Carolina | 29607-3791 | United States | micro | |
| Carolina Bauernhaus Ales | 115 Federal St | Anderson | South Carolina | 29625-4364 | United States | brewpub | |
| Charles Towne Fermentory | 809 Savannah Hwy | Charleston | South Carolina | 29407-7278 | United States | micro | |
| Ciclops Cyderi and Brewery | 197 E Saint John St | Spartanburg | South Carolina | 29306-5121 | United States | brewpub | |
| COAST Brewing Co | 1250 N 2nd St | North Charleston | South Carolina | 29405-1804 | United States | micro | |
| Columbia Craft Brewing Company | 520 Greene St | Columbia | South Carolina | 29201-3612 | United States | brewpub | |
| Commonhouse Aleworks | 4831 Ohear Ave | North Charleston | South Carolina | 29405-4925 | United States | micro | |
| Conquest Brewing Co. | 947 S Stadium Rd | Columbia | South Carolina | 29201-4724 | United States | micro | |
| Cooper River Brewing Company | 2201-B Mechanic St | Charleston | South Carolina | 29405 | United States | micro | |
| CottonTown Brew Lab | 1223 Franklin St | Columbia | South Carolina | 29201-1958 | United States | micro | |
| Dead Eric Brewing Co. LLC | 433 Old House Rd | Ridgeland | South Carolina | 29936-6946 | United States | micro | |
| Dockery's | 186 Seven Farms Dr Ste F399 | Charleston | South Carolina | 29492-8510 | United States | brewpub | |
| Edmund's Oast Brewing Co | 1505 King St Extension | Charleston | South Carolina | 29405 | United States | brewpub | |
| Fam's Brewing Company | 1291 Folly Rd | Charleston | South Carolina | 29412 | United States | brewpub | |
| Fatty's Beer Works | 1436 Meeting Street Rd | Charleston | South Carolina | 29405-9342 | United States | contract | |
| Freehouse Brewery | 2895 Pringle St Ste B | Charleston | South Carolina | 29405-7506 | United States | micro | |
| Frothy Beard Brewing Co | 1401 Sam Rittenberg Blvd Ste 1 | Charleston | South Carolina | 29407-5031 | United States | micro | |
| Full Spectrum Brewing Co | 2180 Carolina Place Dr Ste 101 | Fort Mill | South Carolina | 29708-7002 | United States | micro | |
| Ghost Monkey Brewery | 522 Wando Ln | Mount Pleasant | South Carolina | 29464-8211 | United States | micro | |
| Good Times Brewing | 237 Maxwell Ave | Greenwood | South Carolina | 29646-2616 | United States | brewpub | |
| Gordon Biersch Brewery Restaurant - Myrtle Beach | 3060 Howard Ave | Myrtle Beach | South Carolina | 29577-1643 | United States | brewpub | |
| Hazelwood Brewing Company | | Lexington | South Carolina | 29072 | United States | planning | |
| Hilton Head Brewing Co | 1 Cardinal Ct Ste 13 | Hilton Head Island | South Carolina | 29926-3401 | United States | brewpub | |
| Holy City Brewing | 1021 Aragon Ave | North Charleston | South Carolina | 29405-4903 | United States | micro | |
| Hunter Gatherer Brewery and Alehouse | 900 Main St | Columbia | South Carolina | 29201-3964 | United States | brewpub | |
| Indigo Reef Brewing Company | 2079 Wambaw Creek Unit 1 | Charleston | South Carolina | 29492 | United States | micro | |
| Iron Hill Brewery & Restaurant - Greenville | 741 Haywood Rd | Greenville | South Carolina | 29607 | United States | brewpub | |
| Krafty Draft Brew Pub | 269 Charter Oak Rd | Lexington | South Carolina | 29072-9200 | United States | brewpub | |
| Legal Remedy Brewing | 129 Oakland Ave | Rock Hill | South Carolina | 29730-4019 | United States | brewpub | |
| Liability Brewing Co. | | Greenville | South Carolina | 29609-5559 | United States | planning | |
| Liberty Steakhouse and Brewery | 1321 Celebrity Cir | Myrtle Beach | South Carolina | 29577-7445 | United States | brewpub | |
| Lincoln and South Brewing Co. | | Hilton Head Island | South Carolina | 29928 | United States | planning | |
| Lo-Fi Brewing | 2038 Meeting St Rd | North Charleston | South Carolina | 29405-9357 | United States | micro | |
| Low Tide Brewing | 2863 Maybank Hwy | Johns Island | South Carolina | 29455-4808 | United States | micro | |
| Munkle Brewing Company | 1513 Meeting Street Rd | Charleston | South Carolina | 29405-9301 | United States | micro | |
| New Groove Artisan Brewery | 4078 Highway 9 | Boiling Springs | South Carolina | 29316-8501 | United States | brewpub | |
| New South Brewing Co | 1109 Campbell St | Myrtle Beach | South Carolina | 29577-3527 | United States | micro | |
| Oak Road Brewery | 108 E 3rd North St Ste C | Summerville | South Carolina | 29483-6810 | United States | micro | |
| Old Mill Brewpub | 711 E Main St | Lexington | South Carolina | 29072-3670 | United States | brewpub | |
| Palmetto Brewing Co | 289 Huger St Bldg B | Charleston | South Carolina | 29403-4560 | United States | regional | |
| Pawleys Island Brewing Company | 2668 Industrial Ave | North Charleston | South Carolina | 29405-7429 | United States | brewpub | |
| Quest Brewing Company | 55 Airview Dr | Greenville | South Carolina | 29607-2632 | United States | micro | |
| Quigley's Pint and Plate | 257 Willbrook Blvd | Pawleys Island | South Carolina | 29585-7789 | United States | brewpub | |